![]() Aggressive supportive care is necessary to achieve a successful outcome, and the likelihood of of survival has been proven to be associated with body weight and IV administration of pyridoxine and negatively associated with dose of isoniazid ingested and presence of seizures. When in doubt, rapid diagnosis of isoniazid poisoning in dogs is warranted, as it requires prompt treatment for best survival. In a study by Schmid et al, the probability of survival for isoniazid toxicosis was positively associated with IV administration of pyridoxine and negatively associated with dose of isoniazid ingested and presence of seizures.20 Dogs that received pyridoxine IV were 29X as likely to survive as dogs that did not receive pyridoxine IV.ĭose: suggested dose of 71 mg/kg IV, diluted to 5-10%, slow over 30-60 minutes. Without the administration of pyridoxine, the prognosis is poor for isoniazid toxicosis in dogs. Pyridoxine s converted to pyridoxal phosphate and pyridoxamine and enhances excretion of the toxicant. Pyridoxine is the antidote necessary for isoniazid toxicosis in dogs, and typically needs to be obtained from a human hospital. Thankfully, unlike the majority of toxicants out there in veterinary medicine, isoniazid poisoning has an ANTIDOTE! The antidote pyridoxine hydrochloride (typically available as 100 mg/ml) should be obtained as soon as possible.
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